ea0015p108 | Cytokines and growth factors | SFEBES2008
Hu Youli
, Kim Soo-Hyun
, Guimond Scott
, Quartey-Papafio Ruby
, Cadman Steven
, Travers Paul
, Hoheneste Erhard
, Turnbull Jeremy
, Bouloux Pierre
Introduction: Fibroblast growth factor (FGF) signalling involved in many physiological and pathophysiological processes requires the complex formation of FGF receptor, FGF and heparan sulphate, which is regulated by multiple extracellular inputs. FGFR1 as KAL-2 gene and anosmin-1, an extracellular matrix protein encoded by KAL-1 gene are associated with Kallmann syndrome characterised by anosmia and hypogonadotropic hypogonadism. Anosmin-1 induces neurite outgrowth and cytoske...